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My second postdoc was undertaken at the MRC National Institute for Medical Research, Mill Hill, with Dr Robin Lovell-Badge, FRS.There, we isolated the mouse Y-chromosomal gene and demonstrated its role as the testis-determining gene by reversing the sex of XX transgenic mice.Finally, we discuss sex-determining loci and disorders of sex development in humans and the future of research in this important area.Gonadal sex reversal is a developmental phenomenon that reveals key features of the sex determination process in mammals.I am Chair of the Equity and Diversity Reference Group of the Australian Academy of Science, Chair of the Australian JSPS Alumni Association, on the Board of Directors of the International Society for Differentiation, on the Council of Gordon Research Conferences, a member of the Executive of the Australian and New Zealand Society for Cell and Developmental Biology, and a member of the DSD Subcommittee of the Australasia Pediatric Endocrinology Group.
Homeosis describes the replacement of one embryonic structure by another that switch segment identity to such dramatic effect.
Our fundamental research in molecular genetics and developmental biology has medical application in diagnosis and management of human disorders of sexual development, fertility, and gonadal cancers.
Potential biotechnological applications include drug development, stem cell programming and gender ratio manipulation in pest, wildlife and livestock species.
Some of these, and related problems, are common to organogenesis in general; some are distinctive to gonad development.
In this review, we discuss recent studies of the molecular and cellular events underlying testis and ovary development, with an emphasis on the phenomenon of gonadal sex reversal and its causes in mice and humans.
In 1992 I took up a research group leader position at the University of Queensland, Brisbane.